The first issue in the darkest times - Spider-Event of the year! Flash Thompson, Secret Avenger known as Venom, is back in town for his first clash with the Supreme Spider-Man! Will their first meeting friends or blinks to sense something dangerous about the presence of Peter Parker?

It's all out war ... with Venom, mania, crossbones, DOA, and ... Mephisto? But who is on whose side? The ultimate fate is revealed Mania! Will it keep the symbiote? Is this the end Venom dance with the devil? Or just the beginning?

The return of the most dangerous enemies of Spider-Man: Venom! The sinister symbiote selects a new owner, Harry Osborn! Spider can save his best friend when COMMANDER rage gave orders to kill Venom ... once and for all!