Let me check the Marvel Wiki. Hang on... OK...Deadpool is a guy with guns and swords... is an Eternal with strength, endurance, agility, and nearly invulnerable skin, who can shoot cosmic energy from his eyes and hands. Sounds like a fair fight!
Worst threats ever have / will face Marvel Universe? In Hulkvengers? Kraven on Pheonix? WolfCap? Wolverine King vampires? Cosmic Carnage? Sounds like a job for Longshot, is not it?