This volume of the critically acclaimed series collects issues #49-54! Yorick and Agent 355 prepare for their ultimate quest to reunite the last man with his lost love, while the person, people or thing behind the disaster that wiped out half of humanity is revealed.

The saga of Yorick Brown, the last man on Earth, continues in the sixth volume collecting issues #32-36 of the hit Vertigo series. Yorick, Agent 355 and Dr. Mann ship out across the Pacific to Japan in pursuit of Yorick's stolen monkey Ampersand, whose innards may hold the key to mankind's future.