The Bureau for Paranormal Research and Defense faces its worst tragedy ever as the war against the plague of frogs reaches a devastating new level. Heralded by a bizarre villain from the B.P.R.D.'s past, an ancient monster-god marches across the American heartland portending an end to the reign of men, and leaving a permanent mark on the Bureau.

The Bureau of Paranormal Research and Defense - a private organization founded in 1944 to combat the occult research carried out by Nazi Germany.